بررسی تغییرات آلفا-1 – آنتی تریپسین (1 –AT) در سرم بیماران هیپوتیروئیدی

Alpha-1- Protease inhibitor or a1-Antitrypsin (a1-AT) is an a1-glycoprotein and a small molecule which acts as an extracellular inhibitor of serin proteases. It seems that this molecule protein has a protective role in tissues such as inhibition (inactivation) of elastase, colagenase, etc. a1-AT deficiency is a hereditary disorder which characteristed by reduced a1-AT serum level and may cause emphysema, skin disorders, etc. This study measures alteration of this 27 hypothyroid patients and 30 healthy individuals. T3,T4, TSH was assayed by g-counter and TIC (trypsin inhibitory capacity) by sysnthetic substrate BAEE and using U.V. spectrophotometer. The results showed the TIC in hypothyroid patients was significantly lower than that of healthy individual (1.28U+ 0.148 Vs 1.87 + 0.29 mg/ml). Sina correlation between T3 and TIC for hypothyroid was 0.62, then it should be concluded that trypsin inhibitory capacity and a1-AT concentrration decreased in hypothyroidism and decrease dinsity of dermal elastic fiber.